Publications.

bioRxiv / Preprint

Strand-independent degradation of uncoupled forks by EXO1 activates ATR and restrains fork progression

Emma J Grogan, Obehi E Ozua, Tamar Kavlashvili, Sara C Conwell, James M Dewar

DOI: 10.64898/2026.03.22.666038

bioRxiv / Preprint

Topoisomerase IIIα resolves inter- and intra-molecular intertwines during DNA replication

Sabrina X Van Ravenstein, Lillian V Campos, Gabor M Harami, Darren R Heintzman, Steven N Dahmen, William G Dunphy, Keir C Neuman, James M Dewar

DOI: 10.64898/2026.06.30.735647

Nature Structural & Molecular Biology / Research article

Distinct repair outcomes from single and convergent replication fork collapse

Sara C Conwell, Khushi V N Patel, Savannah J Weeks-Pollenz, Steven N Dahmen, Matthew T Cranford, William G Dunphy, David T Long, David Cortez, James M Dewar

DOI: 10.1038/s41594-026-01812-9

Nucleic Acids Research / Research article

Leading and lagging strand abasic sites differentially affect vertebrate replisome progression but involve analogous bypass mechanisms

Matthew T Cranford, Steven N Dahmen, David Cortez, James M Dewar

DOI: 10.1093/nar/gkaf975

Nature Protocols / Research article

Control of DNA replication in vitro using a reversible replication barrier

Emma J Vontalge, Tamar Kavlashvili, Steven N Dahmen, Matthew T Cranford, James M Dewar

DOI: 10.1038/s41596-024-00977-1

Cell Reports / Research article

RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

Lillian V Campos, Sabrina X Van Ravenstein, Emma J Vontalge, Briana H Greer, Darren R Heintzman, Tamar Kavlashvili, W Hayes McDonald, Kristie Lindsey Rose, Brandt F Eichman, James M Dewar

DOI: 10.1016/j.celrep.2023.112109

Nature Structural & Molecular Biology / Research article

Replication fork uncoupling causes nascent strand degradation and fork reversal

Tamar Kavlashvili, Wenpeng Liu, Taha M Mohamed, David Cortez, James M Dewar

DOI: 10.1038/s41594-022-00871-y

The EMBO Journal / Research article

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

Sabrina X Van Ravenstein, Kavi P Mehta, Tamar Kavlashvili, Jo Ann W Byl, Runxiang Zhao, Neil Osheroff, David Cortez, James M Dewar

DOI: 10.15252/embj.2022110632

Cell Reports / Research article

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

Darren R Heintzman, Lillian V Campos, Jo Ann W Byl, Neil Osheroff, James M Dewar

DOI: 10.1016/j.celrep.2019.08.097

The EMBO Journal / Research article

Initiation of DNA replication requires actin dynamics and formin activity

Nikolaos Parisis, Liliana Krasinska, Bethany Harker, Serge Urbach, Michel Rossignol, Alain Camasses, James Dewar, Nathalie Morin, Daniel Fisher

DOI: 10.15252/embj.201796585

Journal of Molecular Biology / Review

How Topoisomerases Relax and Disentangle the Genome During DNA Replication

James M Dewar

DOI: 10.1016/j.jmb.2026.169989

Nature / Commentary

Want to get more from AI? Treat every prompt like an experiment

James M Dewar

DOI: 10.1038/d41586-026-02083-6

Publisher PDF may require institutional access.

Journal of Molecular Biology / Review

Novel Bacterial Topoisomerase Inhibitors: A New Front in an Old War

Chelsea A Mann, James M Dewar, Neil Osheroff

DOI: 10.1016/j.jmb.2026.169892

Zenodo / Preprint

Large Language Models for Science and Research: A Practical Guide

James M Dewar

DOI: 10.5281/zenodo.19371506

EdArXiv / Preprint

A Pedagogical Framework for Integrating Large Language Models into Biomedical Education

James M Dewar, Madhvi Venkatesh

DOI: 10.35542/osf.io/t8mea_v2

The EMBO Journal / Commentary

DNA replication recruits a friend to overcome a challenging break-up

James M Dewar

DOI: 10.1038/s44318-024-00204-3

Nature Reviews Molecular Cell Biology / Review

Mechanisms of DNA replication termination

James M Dewar, Johannes C Walter

DOI: 10.1038/nrm.2017.42

Methods in Molecular Biology / Methods chapter

Use of Xenopus Egg Extracts to Study the Effects of Topoisomerase Poisons During Vertebrate DNA Replication

Sabrina X Van Ravenstein, James M Dewar

DOI: 10.1007/978-1-0716-4550-5_13

Publisher PDF may require institutional access.

Methods in Enzymology / Methods chapter

Replication fork collapse in vitro using Xenopus egg extracts

Sara C Conwell, Matthew T Cranford, Tamar Kavlashvili, James M Dewar

DOI: 10.1016/bs.mie.2022.03.017

A direct publisher PDF link could not be verified. The chapter page provides institutional access and purchase options.

Methods in Molecular Biology / Methods chapter

Approaches to Monitor Termination of DNA Replication Using Xenopus Egg Extracts

Tamar Kavlashvili, James M Dewar

DOI: 10.1007/978-1-0716-2063-2_7

Publisher PDF may require institutional access.

Includes a published correction.